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1.What is the Tegafur ?
Used as an antineoplastic
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1191-99-7,75454-45-4
2,3-dihydro-2H-furan
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silylated-5-fluoro-uracil
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silylated-5-fluoro-uracil
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51-21-8
5-fluorouracil
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17902-23-7,65732-47-0,79107-97-4
tegafur
| Conditions | Yield |
|---|---|
|
With
sodium iodide;
In
isopropyl alcohol; acetonitrile;
|
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1191-99-7,75454-45-4
2,3-dihydro-2H-furan
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17242-85-2
5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine
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51-21-8
5-fluorouracil
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17902-23-7,65732-47-0,79107-97-4
tegafur
| Conditions | Yield |
|---|---|
|
With
pyridine hydrochloride;
In
chloroform;
at 60 - 70 ℃;
Product distribution;
other temperature, other solvents;
|
44.5%
0.6 g |
2.What is the CAS number for Tegafur ?
The CAS number of Tegafur is 17902-23-7.
More information of Tegafur 17902-23-7 are:
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CAS?Number |
17902-23-7 |
|
Density |
1.45 g/cm3 |
|
Melting Point |
171-173 °C(lit.) |
|
Refractive Index |
1.557 |
|
HS CODE |
29349990 |
|
PSA |
64.09000 |
|
LogP |
-0.01530 |
|
Pka |
7.63±0.10(Predicted) |
3.What are another words for Tegafur ?
Synonyms?for?Tegafur 17902-23-7:1-(2-Tetrahydrofuryl)-5-fluorouracil ; 1-(Tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione;1-(Tetrahydrofuran-2-yl)-5-fluorouracil;2,4(1H,3H)Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-;5-24-06-00285 (Beilstein Handbook Reference);5-Fluoro-1-(tetrahydro-2-furanyl)-2,4-pyrimidinedione;
4.What is the molecular formula of Tegafur?
The chemical formula of ?Tegafur is?C8H9FN2O3 which containing 8 Carbon atoms,9 Hydrogen atoms,1 Fluorine atoms,2 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of??Tegafur?is 200.169.
5.What is Tegafur (17902-23-7) used for?
Tegafur is an orally bioavailable prodrug form of 5-fluorouracil (5-FU; ). It is converted to 5-FU in vivo enzymatically or by cytochrome P450 oxidation. Tegafur inhibits proliferation of HT-29, BxPC-3, and Panc02 cells (IC50s = 201, 172, and 179 μM, respectively). It also reduces tumor growth in an HT-27 colon carcinoma mouse xenograft model when administered at a dose of 50 mg/kg and in a 4-1ST gastric carcinoma mouse xenograft model when used in combination with uracil. Formulations containing tegafur, in combination with uracil, have been used in the treatment of cancer.
InChI:InChI=1/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)/t6-/m1/s1
Relevant articles related to Tegafur:
|
Article |
Source |
|
A novel synthesis of 5-fluorouracil derivatives having oxacycloalkane moieties |
Iwasaki,Nishitani,Horikawa,Inoue , p. 1029 - 1032 (1981) |
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Preparation method of tegafur |
- Paragraph 0030-0055, (2021/04/21) |
6.Buy Tegafur with the best price .
Shijiazhuang Xuanjiang Chemicals Co., Ltd is a quality supplier of Tegafur. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Tegafur 17902-23-7.
